Region 8q24 is a susceptibility locus for nonsyndromic oral clefting in Brazil.

doi:10.1002/bdra.23011

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Article

Region 8q24 is a susceptibility locus for nonsyndromic oral clefting in Brazil.

Birth defects research. Part A, Clinical and molecular teratology - 1 Jun 2012

Brito Luciano Abreu, Paranaiba Lívia Máris Ribeiro, Bassi Camila Fernandes Silva, Masotti Cibele, Malcher Carolina, Schlesinger David, Rocha Katia Maria, Cruz Lucas Alvizi, Bárbara Lígia Kobayashi, Alonso Nivaldo, Franco Diogo, Bagordakis Elizabete, Martelli Hercílio, Meyer Diogo, Coletta Ricardo D, Passos-Bueno Maria Rita

Abstract excerpt

BACKGROUND: Nonsyndromic cleft lip with or without cleft palate is a relatively common craniofacial defect with multifactorial inheritance. The association of the rs987525 single nucleotide variant, located in a gene desert at 8q24.21 region, has been consistently replicated in European populations. We performed a structured association approach combined with transcriptional analysis of the MYC gene to dissect...

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PMID: 22511506
DOI: 10.1002/bdra.23011

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