Article
Physical mapping of a tandem duplication on the long arm of chromosome 7 associated with a multidrug resistant phenotype.
Cancer genetics and cytogenetics - 1 Apr 1999
de Silva M G, Kantharidis P, Scherer S W, Rayeroux K, Campbell L, Tsui L C, Zalcberg J R
Abstract excerpt
Both the expression of the multidrug transporter, P-glycoprotein (Pgp), and abnormalities of the long arm of chromosome 7 have been shown to be adverse prognostic indicators in acute leukemias. In this study, a clonal duplication, dup(7)(q11.1q31.1), inherited with the classical multidrug resistant phenotype in a drug-resistant derivative of a human T-cell leukemia cell line was characterized. The position of the...
Topics
- ATP Binding Cassette Transporter, Subfamily B, Member 1
- Chromosome Aberrations
- Chromosomes, Human, Pair 7
- Drug Resistance, Multiple
- Humans
- Leukemia, T-Cell
- Phenotype
- Physical Chromosome Mapping
- Tumor Cells, Cultured