Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Physical mapping of a tandem duplication on the long arm of chromosome 7 associated with a multidrug resistant phenotype.

Cancer genetics and cytogenetics - 1 Apr 1999

de Silva M G, Kantharidis P, Scherer S W, Rayeroux K, Campbell L, Tsui L C, Zalcberg J R

Abstract excerpt

Both the expression of the multidrug transporter, P-glycoprotein (Pgp), and abnormalities of the long arm of chromosome 7 have been shown to be adverse prognostic indicators in acute leukemias. In this study, a clonal duplication, dup(7)(q11.1q31.1), inherited with the classical multidrug resistant phenotype in a drug-resistant derivative of a human T-cell leukemia cell line was characterized. The position of the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to ATP Binding Cassette Transporter, Subfamily B, Member 1
Share to Chromosome Aberrations

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Chromosomes, Human, Pair 7

Share to Drug Resistance, Multiple

Share to Leukemia, T-Cell

Share to Phenotype

Share to Physical Chromosome Mapping

Share to Tumor Cells, Cultured

Source

Identifiers

PMID: 10198619
DOI: 10.1016/s0165-4608(98)00195-2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Physical mapping of a tandem duplication on the long arm of chromosome 7 associated with a multidrug resistant phenotype.PMID 10198619Read ↗

Inheritance of chromosome 7 is associated with a drug-resistant phenotype in somatic cell hybrids.Semantic proximity Read ↗

Cytogenetic and molecular characterization of random chromosomal rearrangements activating the drug resistance gene,MDR1/P-glycoprotein, in drug-selected cell lines and patients with drug refractory ALLSemantic proximity Read ↗

Not only P-glycoprotein: Amplification of the ABCB1-containing chromosome region 7q21 confers multidrug resistance upon cancer cells by coordinated overexpression of an assortment of resistance-related proteins.Semantic proximity Read ↗

Cytogenetic and molecular delineation of a region of chromosome 7 commonly deleted in malignant myeloid diseases.Semantic proximity Read ↗

Characterization of Gene Rearrangements Leading to Activation of MDR-1Semantic proximity Read ↗

Delineation of multiple deleted regions in 7q in myeloid disordersSemantic proximity Read ↗

Genetic analysis of the multidrug transporter.Semantic proximity Read ↗

Molecular characterization of the recurrent unbalanced translocation der(1;7)(q10;p10).Semantic proximity Read ↗

A patient with duplication (7)(p22.1pter) characterized by array-CGH.Semantic proximity Read ↗

Molecular Cytogenetic Characterization of a Critical Region in Bands 7q35-q36 Commonly Deleted in Malignant Myeloid DisordersSemantic proximity Read ↗

Candidate gene isolation and comparative analysis of a commonly deleted segment of 7q22 implicated in myeloid malignancies.Semantic proximity Read ↗

Characterization of the human MDR1 gene.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.