Article
Molecular characterization of the recurrent unbalanced translocation der(1;7)(q10;p10).
Blood - 1 Oct 2003
Wang Lili, Ogawa Seishi, Hangaishi Akira, Qiao Ying, Hosoya Noriko, Nanya Yasuhito, Ohyashiki Kazuma, Mizoguchi Hideaki, Hirai Hisamaru
Abstract excerpt
An unbalanced translocation der(1;7)(q10; p10) is a nonrandom chromosomal aberration commonly observed in myelodysplastic syndrome and acute myeloid leukemia. We molecularly analyzed the breakpoints of der(1;7)(q10;p10) by quantitative fluorescent in situ hybridization (FISH) analyses using centromeric satellite DNAs mapped to chromosomes 1 and 7 as probes. We found that the signal intensities of 2 centromere...
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