Trisomy 7-harbouring non-random duplication of the mutant MET allele in hereditary papillary renal carcinomas.

doi:10.1038/1727

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Article

Trisomy 7-harbouring non-random duplication of the mutant MET allele in hereditary papillary renal carcinomas.

Nature genetics - 1 Sept 1998

Zhuang Z, Park W S, Pack S, Schmidt L, Vortmeyer A O, Pak E, Pham T, Weil R J, Candidus S, Lubensky I A, Linehan W M, Zbar B, Weirich G

Abstract excerpt

The gene defect for hereditary papillary renal carcinoma (HPRC) has recently been mapped to chromosome 7q, and germline mutations of MET (also known as c-met) at 7q31 have been detected in patients with HPRC (ref. 2). Tumours from these patients commonly show trisomy of chromosome 7 when analysed...

Topics

Adult
Carcinoma, Papillary
Chromosomes, Human, Pair 7
Female
Genetic Markers
Humans
In Situ Hybridization, Fluorescence
Kidney Neoplasms
Male
Mutation
Pedigree
Polymerase Chain Reaction
Proto-Oncogene Proteins c-met
Trisomy

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Open in PubMed

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PMID: 9731534
DOI: 10.1038/1727

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9731534-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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