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Article

Trisomy 7-harbouring non-random duplication of the mutant MET allele in hereditary papillary renal carcinomas.

Nature genetics - 1 Sept 1998

Zhuang Z, Park W S, Pack S, Schmidt L, Vortmeyer A O, Pak E, Pham T, Weil R J, Candidus S, Lubensky I A, Linehan W M, Zbar B, Weirich G

Abstract excerpt

The gene defect for hereditary papillary renal carcinoma (HPRC) has recently been mapped to chromosome 7q, and germline mutations of MET (also known as c-met) at 7q31 have been detected in patients with HPRC (ref. 2). Tumours from these patients commonly show trisomy of chromosome 7 when analysed by cytogenetic studies and comparative genomic hybridization (CGH). However, the relationship between trisomy 7 and...

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Source

Identifiers

PMID: 9731534
DOI: 10.1038/1727

Genes

MET

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 11 closest

Trisomy 7-harbouring non-random duplication of the mutant MET allele in hereditary papillary renal carcinomas.PMID 9731534Read ↗

Duplication and overexpression of the mutant allele of the MET proto-oncogene in multiple hereditary papillary renal cell tumours.Semantic proximity Read ↗

Germline and somatic mutations in the tyrosine kinase domain of the MET proto-oncogene in papillary renal carcinomas.Semantic proximity Read ↗

Common pattern of unusual chromosome abnormalities in hereditary papillary renal carcinoma.Semantic proximity Read ↗

Loss of heterozygosity at 7p in Wilms' tumour development.Semantic proximity Read ↗

Trisomy 7 and 17 mark papillary renal cell tumours irrespectively of variation of the phenotype.Semantic proximity Read ↗

Germline and somatic abnormalities of chromosome 7 in Wilms' tumor.Semantic proximity Read ↗

Analysis by pulsed field gel electrophoresis reveals complex rearrangements in two MET alleles in a chemically-treated human cell line, MNNG-HOS.Semantic proximity Read ↗

Mapping the papillary renal cell carcinoma gene between loci D17S787 and D17S1799 on chromosome 17q21.32.Semantic proximity Read ↗

An LOH and mutational investigation of the ST7 gene locus in human esophageal carcinoma.Semantic proximity Read ↗

Chromosome 7q31 allelic imbalance and somatic mutations of RAY1/ST7 gene in colorectal cancer.Semantic proximity Read ↗

Loss of heterozygosity on chromosome 7q and aggressive primary breast cancer.Semantic proximity Read ↗

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