Article
The S140G KCNQ1 atrial fibrillation mutation affects 'I(KS)' profile during both atrial and ventricular action potentials.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society - 1 Dec 2010
El Harchi A, Zhang H, Hancox J C
Abstract excerpt
KCNQ1 is responsible for the pore-forming subunit of channels that mediate the cardiac 'IKs' potassium channel current. The S140G KCNQ1 gain-of-function mutation is responsible for a form of heritable atrial fibrillation. Here the action potential (AP) voltage clamp technique was used to elucidate the effect of S140G KCNQ1 on the profile of recombinant I(Ks) during atrial and ventricular APs applied to...
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