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Article

Computational simulations of the effects of the G229D KCNQ1 mutation on human atrial fibrillation.

The journal of physiological sciences : JPS - 1 Sept 2016

Zulfa Indana, Shim Eun Bo, Song Kwang-Soup, Lim Ki Moo

Abstract excerpt

Atrial fibrillation (AF) is related to mutations at the genetic level. This includes mutations in genes that encode KCNQ1, a subunit of the I Ks channel. Here, we investigate the mechanism of gain-of-function in I Ks towards the occurrence of AF. We used the Courtemanche-Ramirez-Nattel (CRN) human atrial cell model (Am J Physiol Heart Circ Physiol 275:H301-H321, 1998) and applied the modification proposed by...

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Identifiers

PMID: 26922794
DOI: 10.1007/s12576-016-0438-3
PMCID: PMC10717180

Genes

KCNQ1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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