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Article

Atrial proarrhythmia due to increased inward rectifier current (I(K1)) arising from KCNJ2 mutation--a simulation study.

Progress in biophysics and molecular biology - 1 Jan 2000

Kharche Sanjay, Garratt Clifford J, Boyett Mark R, Inada Shin, Holden Arun V, Hancox Jules C, Zhang Henggui

Abstract excerpt

Atrial fibrillation (AF) has been linked to increased inward rectifier potassium current, I(K1), either due to AF-induced electrical remodelling, or from functional changes due to the Kir2.1 V93I mutation. The aim of this simulation study was to identify at cell and tissue levels' mechanisms by which increased I(K1) facilitates and perpetuates AF. The Courtemanche et al. human atrial cell action potential (AP)...

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Source

Identifiers

PMID: 19041665
DOI: 10.1016/j.pbiomolbio.2008.10.010

Genes

KCNJ2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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