Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

In silico investigation of a KCNQ1 mutation associated with familial atrial fibrillation.

Journal of electrocardiology - 1 Jan 2000

Hancox J C, Kharche S, El Harchi A, Stott J, Law P, Zhang H

Abstract excerpt

Mutations in transmembrane domains of the KCNQ1 subunit of the I(Ks) potassium channel have been associated with familial atrial fibrillation. We have investigated mechanisms by which the S1 domain S140G KCNQ1 mutation influences atrial arrhythmia risk and, additionally, whether it can affect ventricular electrophysiology. In perforated-patch recordings, S140G-KCNQ1+KCNE1 exhibited leftward-shifted activation,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Action Potentials
Share to Atrial Fibrillation
Share to CHO Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Computer Simulation

Share to Cricetulus

Share to KCNQ1 Potassium Channel

Share to Mutation

Share to Patch-Clamp Techniques

Source

Identifiers

PMID: 24411289
DOI: 10.1016/j.jelectrocard.2013.12.004

Genes

KCNQ1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

In silico investigation of a KCNQ1 mutation associated with familial atrial fibrillation.PMID 24411289Read ↗

Pro-arrhythmogenic effects of the S140G KCNQ1 mutation in human atrial fibrillation - insights from modelling.Semantic proximity Read ↗

KCNQ1 gain-of-function mutation in familial atrial fibrillation.Semantic proximity Read ↗

Augmented potassium current is a shared phenotype for two genetic defects associated with familial atrial fibrillation.Semantic proximity Read ↗

The S140G KCNQ1 atrial fibrillation mutation affects 'I(KS)' profile during both atrial and ventricular action potentials.Semantic proximity Read ↗

Selective targeting of gain-of-function KCNQ1 mutations predisposing to atrial fibrillation.Semantic proximity Read ↗

Mechanisms by which atrial fibrillation-associated mutations in the S1 domain of KCNQ1 slow deactivation of IKs channels.Semantic proximity Read ↗

Proarrhythmia in KCNJ2-linked short QT syndrome: insights from modelling.Semantic proximity Read ↗

Human Atrial Arrhythmogenesis and Sinus Bradycardia in KCNQ1-Linked Short QT Syndrome: Insights From Computational ModellingSemantic proximity Read ↗

Computational simulations of the effects of the G229D KCNQ1 mutation on human atrial fibrillation.Semantic proximity Read ↗

Characterization of KCNQ1 atrial fibrillation mutations reveals distinct dependence on KCNE1.Semantic proximity Read ↗

Computational prediction of proarrhythmogenic effect of the V241F KCNQ1 mutation in human atrium.Semantic proximity Read ↗

Atrial proarrhythmia due to increased inward rectifier current (I(K1)) arising from KCNJ2 mutation--a simulation study.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.