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Article

Computational prediction of proarrhythmogenic effect of the V241F KCNQ1 mutation in human atrium.

Progress in biophysics and molecular biology - 1 Sept 2014

Imaniastuti Riski, Lee Hyun Seung, Kim Nari, Youm Jae Boum, Shim Eun Bo, Lim Ki Moo

Abstract excerpt

Genetic factors play an important role in the pathogenesis of atrial flutter (AF). Although mutation in KCNQ1 has been widely correlated with AF, the mechanism by which mutation promotes AF remains poorly understood. The purpose of this study was to investigate the proarrhythmic effect of V241F KCNQ1 mutation in human atrium using the electrophysiological model of human atrium. Using 2D and 3D cardiac...

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Source

Identifiers

PMID: 25230101
DOI: 10.1016/j.pbiomolbio.2014.09.001

Genes

KCNQ1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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