Article
Haplotype analyses of haemoglobin C and haemoglobin S and the dynamics of the evolutionary response to malaria in Kassena-Nankana District of Ghana.
PloS one - 1 Jan 2012
Ghansah Anita, Rockett Kirk A, Clark Taane G, Wilson Michael D, Koram Kwadwo A, Oduro Abraham R, Amenga-Etego Lucas, Anyorigiya Thomas, Hodgson Abraham, Milligan Paul, Rogers William O, Kwiatkowski Dominic P
Abstract excerpt
BACKGROUND: Haemoglobin S (HbS) and C (HbC) are variants of the HBB gene which both protect against malaria. It is not clear, however, how these two alleles have evolved in the West African countries where they co-exist at high frequencies. Here we use haplotypic signatures of selection to investigate the evolutionary history of the malaria-protective alleles HbS and HbC in the Kassena-Nankana District (KND) of...
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