Article
Classical sickle beta-globin haplotypes exhibit a high degree of long-range haplotype similarity in African and Afro-Caribbean populations.
BMC genetics - 10 Aug 2007
Hanchard Neil, Elzein Abier, Trafford Clare, Rockett Kirk, Pinder Margaret, Jallow Muminatou, Harding Rosalind, Kwiatkowski Dominic, McKenzie Colin
Abstract excerpt
BACKGROUND: The sickle (betas) mutation in the beta-globin gene (HBB) occurs on five "classical" betas haplotype backgrounds in ethnic groups of African ancestry. Strong selection in favour of the betas allele - a consequence of protection from severe malarial infection afforded by heterozygotes - has been associated with a high degree of extended haplotype similarity. The relationship between classical betas...
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