The effects of a single nucleotide polymorphism in SLCO1B1 on the pharmacodynamics of pravastatin.

doi:10.1111/j.1365-2125.2011.04090.x

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Article

The effects of a single nucleotide polymorphism in SLCO1B1 on the pharmacodynamics of pravastatin.

British journal of clinical pharmacology - 1 Feb 2012

Martin Nicholas G, Li Ka Wah, Murray Heather, Putt Wendy, Packard Chris J, Humphries Steve E

Abstract excerpt

AIM: To determine whether the SNP rs4149056 in SLCO1B1 alters the pharmacodynamics of pravastatin. METHODS: rs4149056 was genotyped in 626 pravastatin-treated participants in the WOSCOPS trial and the response after 1 year of treatment was compared between the different genotypes. RESULTS: Pravastatin reduced serum LDL cholesterol by 22.2% in TT homozygotes, by 22.2% in TC heterozygotes and by 17.7% in CC...

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Analysis of Variance
Anticholesteremic Agents

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Cholesterol

Liver-Specific Organic Anion Transporter 1

Organic Anion Transporters

Pravastatin

Scotland

Time Factors

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PMID: 21851379
DOI: 10.1111/j.1365-2125.2011.04090.x
PMCID: PMC3269589

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