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Article

Pharmacogenetics of OATP transporters reveals that SLCO1B1 c.388A>G variant is determinant of increased atorvastatin response.

International journal of molecular sciences - 1 Jan 2011

Rodrigues Alice C, Perin Paula M S, Purim Sheila G, Silbiger Vivian N, Genvigir Fabiana D V, Willrich Maria Alice V, Arazi Simone S, Luchessi Andre D, Hirata Mario H, Bernik Marcia M S, Dorea Egidio L, Santos Carla, Faludi Andre A, Bertolami Marcelo C, Salas Antonio, Freire Ana, Lareu Maria V, Phillips Christopher, Porras-Hurtado Liliana, Fondevila Manuel, Carracedo Angel, Hirata Rosario D C

Abstract excerpt

AIMS: The relationship between variants in SLCO1B1 and SLCO2B1 genes and lipid-lowering response to atorvastatin was investigated. MATERIAL AND METHODS: One-hundred-thirty-six unrelated individuals with hypercholesterolemia were selected and treated with atorvastatin (10 mg/day/4 weeks). They were genotyped with a panel of ancestry informative markers for individual African component of ancestry (ACA) estimation...

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Anticholesteremic Agents
Atorvastatin
Heptanoic Acids
Hypercholesterolemia

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Liver-Specific Organic Anion Transporter 1

Organic Anion Transporters

Pharmacogenetics

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PMID: 22016628
DOI: 10.3390/ijms12095815
PMCID: PMC3189752

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