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Article

Structure of the His269Arg mutant of the rat aldose reductase-like protein AKR1B14 complexed with NADPH.

Acta crystallographica. Section F, Structural biology and crystallization communications - 1 Apr 2012

Sundaram Krithika, Endo Satoshi, Matsunaga Toshiyuki, Tanaka Nobutada, Hara Akira, El-Kabbani Ossama

Abstract excerpt

Rat aldose reductase-like protein (AKR1B14) is an orthologue of mouse vas deferens protein (AKR1B7) and plays roles in the detoxification of reactive aldehydes and synthesis of prostaglandin F(2α). Here, the 1.87 Å resolution crystal structure of the His269Arg mutant of AKR1B14 complexed with NADPH is described and shows that the negatively charged 2'-phosphate group of the coenzyme forms an ionic interaction...

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Identifiers

PMID: 22505406
DOI: 10.1107/S1744309112008810
PMCID: PMC3325806

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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