Article
Identification of the amino acid residue of CYP27B1 responsible for binding of 25-hydroxyvitamin D3 whose mutation causes vitamin D-dependent rickets type 1.
The Journal of biological chemistry - 26 Aug 2005
Yamamoto Keiko, Uchida Eriko, Urushino Naoko, Sakaki Toshiyuki, Kagawa Norio, Sawada Natsumi, Kamakura Masaki, Kato Shigeaki, Inouye Kuniyo, Yamada Sachiko
Abstract excerpt
We previously reported the three-dimensional structure of human CYP27B1 (25-hydroxyvitamin D3 1alpha-hydroxylase) constructed by homology modeling. Using the three-dimensional model we studied the docking of the substrate, 25-hydroxyvitamin D3, into the substrate binding pocket of CYP27B1. In this study, we focused on the amino acid residues whose point mutations cause vitamin D-dependent rickets type 1,...
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