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Article

Structural and mutational studies on an aldo-keto reductase AKR5C3 from Gluconobacter oxydans.

Protein science : a publication of the Protein Society - 1 Nov 2014

Liu Xu, Wang Chao, Zhang Lujia, Yao Zhiqiang, Cui Dongbing, Wu Liang, Lin Jinping, Yuan Yu-Ren Adam, Wei Dongzhi

Abstract excerpt

An aldo-keto reductase AKR5C3 from Gluconobacter oxydans (designated as Gox0644) is a useful enzyme with various substrates, including aldehydes, diacetyl, keto esters, and α-ketocarbonyl compounds. The crystal structures of AKR5C3 in apoform in complex with NADPH and the D53A mutant (AKR5C3(-D53A) ) in complex with NADPH are presented herein. Structure comparison and site-directed mutagenesis combined with...

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PMID: 25131535
DOI: 10.1002/pro.2531
PMCID: PMC4241105

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