Article

Crystal structure of steroid reductase SRD5A reveals conserved steroid reduction mechanism

2020-07-23

Abstract excerpt

Steroid hormones are essential in stress response, immune system regulation, and reproduction in mammals. Steroids with 3-oxo-Δ 4 structure, such as testosterone, androstenedione and progesterone, could be catalyzed by steroid 5α-reductases (SRD5As) to generate their corresponding 3-oxo-5α steroids, which are essential for multiple physiological and pathological processes. Abnormal activities of SRD5As will lead...

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Literature Corpus work: 26cc82f8-65cd-569c-856c-6296583f5571
DOI: 10.1101/2020.07.23.217620

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