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Article

Altered specificity mutations define residues essential for substrate positioning in xanthine dehydrogenase.

Journal of molecular biology - 1 May 1998

Glatigny A, Hof P, Romão M J, Huber R, Scazzocchio C

Abstract excerpt

We describe the sequence changes of a number of mutations of the Aspergillus nidulans xanthine dehydrogenase (XDH). We have located the amino acids affected by these changes in the three-dimensional (3D) structure of aldehyde oxido-reductase (MOP) from Desulfovibrio gigas, related to eukaryotic XDHs. Of these, two are loss of function mutations, mapping, respectively, in the molybdenum-pterin co-factor (MoCo)...

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Source

Identifiers

PMID: 9571062
DOI: 10.1006/jmbi.1998.1707

Genes

XDH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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