Article
Metabolic insight into mechanisms of high-altitude adaptation in Tibetans.
Molecular genetics and metabolism - 1 Jun 2012
Ge Ri-Li, Simonson Tatum S, Cooksey Robert C, Tanna Uran, Qin Ga, Huff Chad D, Witherspoon David J, Xing Jinchuan, Zhengzhong Bai, Prchal Josef T, Jorde Lynn B, McClain Donald A
Abstract excerpt
Recent studies have identified genes involved in high-altitude adaptation in Tibetans. Genetic variants/haplotypes within regions containing three of these genes (EPAS1, EGLN1, and PPARA) are associated with relatively decreased hemoglobin levels observed in Tibetans at high altitude, providing corroborative evidence for genetic adaptation to this extreme environment. The mechanisms that afford adaptation to...
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