Article

Comparative transcriptomics of iPSC-derived cardiomyocytes in a high and a low altitude population

2025-06-04

Abstract excerpt

Tibetan adaptation to high-altitude hypoxia remains a classic example of Darwinian selection in humans. To identify adaptive traits that might have evolved in Tibetans in response to long-term exposure to hypoxia, we previously established a library of induced pluripotent stem cells (iPSCs), derived from Tibetan and Han Chinese individuals, as a robust model system for the exploration of condition-specific molecul...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 822e0470-9df8-5508-865d-94a175596e7e
DOI: 10.1101/2025.06.04.657917

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Comparative transcriptomics of iPSC-derived cardiomyocytes in a high and a low altitude populationDOI 10.1101/2025.06.04.657917Read

Transcriptomic analysis of iPSC-derived endothelium reveals adaptations to high altitude hypoxia in energy metabolism and inflammationSemantic proximity Read

Comparative transcriptomic and proteomic analyses provide insights into the key genes involved in high-altitude adaptation in the Tibetan pigSemantic proximity Read

Human adaptation to the hypoxia of high altitude: the Tibetan paradigm from the pregenomic to the postgenomic era.Semantic proximity Read

Genetic evidence for high-altitude adaptation in Tibet.Semantic proximity Read

Single‐cell transcriptomic survey of cell diversity and functional changes in yak hearts at different altitudeSemantic proximity Read

Inter-species differences in response to hypoxia in iPSC-derived cardiomyocytes from humans and chimpanzeesSemantic proximity Read

The Expression Regulatory Network in the Lung Tissue of Tibetan Pigs Provides Insight Into Hypoxia-Sensitive Pathways in High-Altitude HypoxiaSemantic proximity Read

Tibetans living at sea level have a hyporesponsive hypoxia-inducible factor system and blunted physiological responses to hypoxia.Semantic proximity Read

Genetic determinants of Tibetan high-altitude adaptation.Semantic proximity Read

Exome sequencing reveals genetic differentiation due to high-altitude adaptation in the Tibetan cashmere goat (Capra hircus).Semantic proximity Read

Genetic characterization of Tibetan pigs adapted to high altitude under natural selection based on a large whole-genome dataset.Semantic proximity Read

Shared and unique signals of high-altitude adaptation in geographically distinct Tibetan populations.Semantic proximity Read