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Article

Apolipoprotein epsilon 3 alleles are associated with indicators of neuronal resilience.

BMC medicine - 13 Apr 2012

Aboud Orwa, Mrak Robert E, Boop Frederick, Griffin Sue T

Abstract excerpt

BACKGROUND: Epilepsy is associated with precocious development of Alzheimer-type neuropathological changes, including appearance of senile plaques, neuronal loss and glial activation. As inheritance of APOE ε4 allele(s) is reported to favor this outcome, we sought to investigate neuronal and glial responses that differ according to APOE genotype. With an eye toward defining ways in which APOE ε3 alleles may...

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Source

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Identifiers

PMID: 22502727
DOI: 10.1186/1741-7015-10-35
PMCID: PMC3352297

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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