Article
Apolipoprotein E isoforms and susceptibility to genetic generalized epilepsies.
The International journal of neuroscience - 1 Sept 2020
Chaves João, Martins-Ferreira Ricardo, Carvalho Cláudia, Bettencourt Andreia, Brás Sandra, Chorão Rui, Freitas Joel, Samões Raquel, Lopes João, Ramalheira João, Silva Berta M, Pinho E Costa Paulo, da Silva António Martins, Leal Bárbara
Abstract excerpt
Background: Apolipoprotein E (ApoE) is the main lipoprotein secreted in brain. It has a critical immunomodulatory function, influences neurotransmission and it is involved in repairing damaged neurons. ApoE e4 is an isoform of ApoE with altered function, and was previously associated with early onset epilepsy and refractoriness, both in animal models and in patients with focal epilepsies. There is a limited...
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