Article
Increased risk of lung cancer associated with a functionally impaired polymorphic variant of the human DNA glycosylase NEIL2.
DNA repair - 1 Jun 2012
Dey Sanjib, Maiti Amit K, Hegde Muralidhar L, Hegde Pavana M, Boldogh Istvan, Sarkar Partha S, Abdel-Rahman Sherif Z, Sarker Altaf H, Hang Bo, Xie Jingwu, Tomkinson Alan E, Zhou Mian, Shen Binghui, Wang Guanghai, Wu Chen, Yu Dianke, Lin Dongxin, Cardenas Victor, Hazra Tapas K
Abstract excerpt
Human NEIL2, one of five oxidized base-specific DNA glycosylases, is unique in preferentially repairing oxidative damage in transcribed genes. Here we show that depletion of NEIL2 causes a 6-7-fold increase in spontaneous mutation frequency in the HPRT gene of the V79 Chinese hamster lung cell line. This prompted us to screen for NEIL2 variants in lung cancer patients' genomic DNA. We identified several...
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