Article
Increased risk of lung cancer associated with a functionally impaired polymorphic variant of the human DNA glycosylase NEIL2.
DNA repair - 1 Jun 2012
Dey Sanjib, Maiti Amit K, Hegde Muralidhar L, Hegde Pavana M, Boldogh Istvan, Sarkar Partha S, Abdel-Rahman Sherif Z, Sarker Altaf H, Hang Bo, Xie Jingwu, Tomkinson Alan E, Zhou Mian, Shen Binghui, Wang Guanghai, Wu Chen, Yu Dianke, Lin Dongxin, Cardenas Victor, Hazra Tapas K
Abstract excerpt
Human NEIL2, one of five oxidized base-specific DNA glycosylases, is unique in preferentially repairing oxidative damage in transcribed genes. Here we show that depletion of NEIL2 causes a 6-7-fold increase in spontaneous mutation frequency in the HPRT gene of the V79 Chinese hamster lung cell li...
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