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Article

Abnormal Expressions of DNA Glycosylase Genes NEIL1, NEIL2, and NEIL3 Are Associated with Somatic Mutation Loads in Human Cancer.

Oxidative medicine and cellular longevity - 1 Jan 2016

Shinmura Kazuya, Kato Hisami, Kawanishi Yuichi, Igarashi Hisaki, Goto Masanori, Tao Hong, Inoue Yusuke, Nakamura Satoki, Misawa Kiyoshi, Mineta Hiroyuki, Sugimura Haruhiko

Abstract excerpt

The effects of abnormalities in the DNA glycosylases NEIL1, NEIL2, and NEIL3 on human cancer have not been fully elucidated. In this paper, we found that the median somatic total mutation loads and the median somatic single nucleotide mutation loads exhibited significant inverse correlations with the median NEIL1 and NEIL2 expression levels and a significant positive correlation with the median NEIL3 expression...

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Share to Cell Line, Tumor
Share to DNA-(Apurinic or Apyrimidinic Site) Lyase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Glycosylases

Share to DNA Methylation

Share to Gene Expression Regulation, Enzymologic

Share to Gene Expression Regulation, Neoplastic

Share to N-Glycosyl Hydrolases

Share to Neoplasms

Source

Open in PubMed Open full text

Identifiers

PMID: 27042257
DOI: 10.1155/2016/1546392
PMCID: PMC4794593

Genes

NEIL1
NEIL3
NEIL2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Abnormal Expressions of DNA Glycosylase Genes NEIL1, NEIL2, and NEIL3 Are Associated with Somatic Mutation Loads in Human Cancer.PMID 27042257Read ↗

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