Article
Overexpression of NEIL3 associated with altered genome and poor survival in selected types of human cancer.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine - 1 May 2020
Tran Oanh Tn, Tadesse Serkalem, Chu Christopher, Kidane Dawit
Abstract excerpt
Base excision repair, which is initiated by the DNA N-glycosylase proteins, is the frontline for repairing potentially mutagenic DNA base damage. Several base excision repair genes are deregulated in cancer and affect cellular outcomes to chemotherapy and carcinogenesis. Endonuclease VIII-like 3 (NEIL3) is a DNA glycosylase protein that is involved in oxidative and interstrand crosslink DNA damage repair. Our...
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