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Article

Desmoglein 3 anchors telogen hair in the follicle.

Journal of cell science - 1 Sept 1998

Koch P J, Mahoney M G, Cotsarelis G, Rothenberger K, Lavker R M, Stanley J R

Abstract excerpt

Little is known about the function of desmosomes in the normal structure and function of hair. Therefore, it was surprising that mice without desmoglein 3 (the autoantigen in pemphigus vulgaris) not only developed mucous membrane and skin lesions like pemphigus patients, but also developed hair loss. Analysis of this phenotype indicated that hair was normal through the first growth phase ('follicular...

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Source

Identifiers

PMID: 9701552
DOI: 10.1242/jcs.111.17.2529

Genes

DSG3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Desmoglein 3 anchors telogen hair in the follicle.PMID 9701552Read ↗

Expression of desmoglein 1 compensates for genetic loss of desmoglein 3 in keratinocyte adhesion.Semantic proximity Read ↗

Desmoglein 4 in hair follicle differentiation and epidermal adhesion: evidence from inherited hypotrichosis and acquired pemphigus vulgaris.Semantic proximity Read ↗

Roles of GasderminA3 in Catagen-Telogen Transition During Hair Cycling.Semantic proximity Read ↗

Plakophilin-3-deficient mice develop hair coat abnormalities and are prone to cutaneous inflammation.Semantic proximity Read ↗

Corneodesmosin gene ablation induces lethal skin-barrier disruption and hair-follicle degeneration related to desmosome dysfunctionSemantic proximity Read ↗

Ultrastructural changes in mice actively producing antibodies to desmoglein 3 parallel those in patients with pemphigus vulgaris.Semantic proximity Read ↗

Epidermal transglutaminase (TGase 3) is required for proper hair development, but not the formation of the epidermal barrier.Semantic proximity Read ↗

Loss of desmocollin 3 in mice leads to epidermal blistering.Semantic proximity Read ↗

Targeted disruption of the pemphigus vulgaris antigen (desmoglein 3) gene in mice causes loss of keratinocyte cell adhesion with a phenotype similar to pemphigus vulgaris.Semantic proximity Read ↗

Loss of flotillin expression results in weakened desmosomal adhesion and Pemphigus vulgaris-like localisation of desmoglein-3 in human keratinocytesSemantic proximity Read ↗

A spontaneous deletion within the desmoglein 3 extracellular domain of mice results in hypomorphic protein expression, immunodeficiency, and a wasting disease phenotype.Semantic proximity Read ↗

Desmoglein 4 is expressed in highly differentiated keratinocytes and trichocytes in human epidermis and hair follicleSemantic proximity Read ↗

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