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Article

Loss of desmocollin 3 in mice leads to epidermal blistering.

Journal of cell science - 1 Sept 2008

Chen Jiangli, Den Zhining, Koch Peter J

Abstract excerpt

Desmocollin 3 (DSC3) belongs to a subfamily of cadherins and is a major component of desmosomes in keratinocytes of stratified epithelia, such as the epidermis. Based on its amino acid sequence homology to classical cadherins, such as E-cadherin, it has been postulated that DSC3 functions as a cell-adhesion molecule. To test this hypothesis, we assessed the function of DSC3 in the development and maintenance of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18682494
DOI: 10.1242/jcs.031518
PMCID: PMC2659849

Genes

DSC3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Loss of desmocollin 3 in mice leads to epidermal blistering.PMID 18682494Read ↗

Loss of Desmocollin 3 in skin tumor development and progression.Semantic proximity Read ↗

A spontaneous deletion within the desmoglein 3 extracellular domain of mice results in hypomorphic protein expression, immunodeficiency, and a wasting disease phenotype.Semantic proximity Read ↗

Mice lacking desmocollin 1 show epidermal fragility accompanied by barrier defects and abnormal differentiation.Semantic proximity Read ↗

Loss of cell adhesion in Dsg3bal-Pas mice with homozygous deletion mutation (2079del14) in the desmoglein 3 gene.Semantic proximity Read ↗

Targeted disruption of the pemphigus vulgaris antigen (desmoglein 3) gene in mice causes loss of keratinocyte cell adhesion with a phenotype similar to pemphigus vulgaris.Semantic proximity Read ↗

Ultrastructural changes in mice actively producing antibodies to desmoglein 3 parallel those in patients with pemphigus vulgaris.Semantic proximity Read ↗

Expression of desmoglein 1 compensates for genetic loss of desmoglein 3 in keratinocyte adhesion.Semantic proximity Read ↗

Corneodesmosin gene ablation induces lethal skin-barrier disruption and hair-follicle degeneration related to desmosome dysfunctionSemantic proximity Read ↗

Desmoplakin is essential in epidermal sheet formation.Semantic proximity Read ↗

Skin fragility and impaired desmosomal adhesion in mice lacking all keratins.Semantic proximity Read ↗

Suprabasal Desmoglein 3 Expression in the Epidermis of Transgenic Mice Results in Hyperproliferation and Abnormal DifferentiationSemantic proximity Read ↗

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