Distinguishing between longevity and buffered-deleterious genotypes for exceptional human longevity: the case of the MTP gene.

doi:10.1093/gerona/gls103

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Article

Distinguishing between longevity and buffered-deleterious genotypes for exceptional human longevity: the case of the MTP gene.

The journals of gerontology. Series A, Biological sciences and medical sciences - 1 Nov 2012

Huffman Derek M, Deelen Joris, Ye Kenny, Bergman Aviv, Slagboom Eline P, Barzilai Nir, Atzmon Gil

Abstract excerpt

The single nucleotide polymorphism, rs2866164, in the MTP gene, has been associated with human longevity but has not been validated by subsequent longevity studies. Using our population of Ashkenazi Jews, we find that the MTP CC genotype is significantly overrepresented in centenarians and their offspring, as compared with controls (p < .05). However, when we examined MTP CC genotype frequency pattern with aging,...

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PMID: 22496539
DOI: 10.1093/gerona/gls103
PMCID: PMC3668387

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