Article
Human longevity within an evolutionary perspective: the peculiar paradigm of a post-reproductive genetics.
Experimental gerontology - 1 Feb 2008
Capri Miriam, Salvioli Stefano, Monti Daniela, Caruso Calogero, Candore Giuseppina, Vasto Sonya, Olivieri Fabiola, Marchegiani Francesca, Sansoni Paolo, Baggio Giovannella, Mari Daniela, Passarino Giuseppe, De Benedictis Giovanna, Franceschi Claudio
Abstract excerpt
The data we collected on the genetics of human longevity, mostly resulting from studies on centenarians, indicate that: (1) centenarians and long-living sib-pairs are a good choice for the study of human longevity, because they represent an extreme phenotype, i.e., the survival tail of the population who escaped neonatal mortality, pre-antibiotic era illnesses, and fatal outcomes of age-related complex diseases....
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