Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Buffering mechanisms in aging: a systems approach toward uncovering the genetic component of aging.

PLoS computational biology - 1 Aug 2007

Bergman Aviv, Atzmon Gil, Ye Kenny, MacCarthy Thomas, Barzilai Nir

Abstract excerpt

An unrealized potential to understand the genetic basis of aging in humans, is to consider the immense survival advantage of the rare individuals who live 100 years or more. The Longevity Gene Study was initiated in 1998 at the Albert Einstein College of Medicine to investigate longevity genes in a selected population: the "oldest old" Ashkenazi Jews, 95 years of age and older, and their children. The study...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aging
Share to Computer Simulation
Share to Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetics, Population

Share to Genotype

Share to Longevity

Share to Models, Genetic

Share to Survival Rate

Source

Open in PubMed Open full text

Identifiers

PMID: 17784782
DOI: 10.1371/journal.pcbi.0030170
PMCID: PMC1963511

Genes

CETP
LPA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Buffering mechanisms in aging: a systems approach toward uncovering the genetic component of aging.PMID 17784782Read ↗

Pleiotropic Associations of Allelic Variants in a 2q22 Region with Risks of Major Human Diseases and Mortality.Semantic proximity Read ↗

Lipid and Alzheimer's disease genes associated with healthy aging and longevity in healthy oldest-old.Semantic proximity Read ↗

How the effects of aging and stresses of life are integrated in mortality rates: insights for genetic studies of human health and longevity.Semantic proximity Read ↗

Centenarians as extreme phenotypes: An ecological perspective to get insight into the relationship between the genetics of longevity and age-associated diseases.Semantic proximity Read ↗

Causes, effects, and constraints in the genetics of human longevity.Semantic proximity Read ↗

Identifying the genomic determinants of aging and longevity in human population studies: progress and challenges.Semantic proximity Read ↗

Genetics of Human Longevity Within an Eco-Evolutionary Nature-Nurture FrameworkSemantic proximity Read ↗

Genetics of healthy aging and longevity.Semantic proximity Read ↗

Genetic epidemiology in aging research.Semantic proximity Read ↗

Genome-Environment Interactions That Modulate Aging: Powerful Targets for Drug DiscoverySemantic proximity Read ↗

Distinguishing between longevity and buffered-deleterious genotypes for exceptional human longevity: the case of the MTP gene.Semantic proximity Read ↗

APOE ɛ4 allele and TOMM40-APOC1 variants jointly contribute to survival to older ages.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.