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Article

Genetic dissection of a model complex trait using the Drosophila Synthetic Population Resource.

Genome research - 1 Aug 2012

King Elizabeth G, Merkes Chris M, McNeil Casey L, Hoofer Steven R, Sen Saunak, Broman Karl W, Long Anthony D, Macdonald Stuart J

Abstract excerpt

Genetic dissection of complex, polygenic trait variation is a key goal of medical and evolutionary genetics. Attempts to identify genetic variants underlying complex traits have been plagued by low mapping resolution in traditional linkage studies, and an inability to identify variants that cumulatively explain the bulk of standing genetic variation in genome-wide association studies (GWAS). Thus, much of the...

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PMID: 22496517
DOI: 10.1101/gr.134031.111
PMCID: PMC3409269

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