Article
Accurate, ultra-low coverage genome reconstruction and association studies in Hybrid Swarm mapping populations.
G3 (Bethesda, Md.) - 15 Apr 2021
Weller Cory A, Tilk Susanne, Rajpurohit Subhash, Bergland Alan O
Abstract excerpt
Genetic association studies seek to uncover the link between genotype and phenotype, and often utilize inbred reference panels as a replicable source of genetic variation. However, inbred reference panels can differ substantially from wild populations in their genotypic distribution, patterns of linkage-disequilibrium, and nucleotide diversity. As a result, associations discovered using inbred reference panels...
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