Article
Genetic dissection of complex traits.
Science (New York, N.Y.) - 30 Sept 1994
Lander E S, Schork N J
Abstract excerpt
Medical genetics was revolutionized during the 1980s by the application of genetic mapping to locate the genes responsible for simple Mendelian diseases. Most diseases and traits, however, do not follow simple inheritance patterns. Genetics have thus begun taking up the even greater challenge of the genetic dissection of complex traits. Four major approaches have been developed: linkage analysis, allele-sharing...
Topics
- Alleles
- Animals
- Chromosome Mapping
- Cloning, Molecular
- Crosses, Genetic
- Female
- Genetic Linkage
- Genetic Markers
- Genetic Predisposition to Disease
- Genetics, Medical
- Genotype
- Humans