Article
Role of functional genetic variation in the dopamine D2 receptor (DRD2) in response to bupropion and nicotine replacement therapy for tobacco dependence: results of two randomized clinical trials.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Jan 2006
Lerman Caryn, Jepson Christopher, Wileyto E Paul, Epstein Leonard H, Rukstalis Margaret, Patterson Freda, Kaufmann Vyga, Restine Stephanie, Hawk Larry, Niaura Ray, Berrettini Wade
Abstract excerpt
Although bupropion and nicotine replacement therapy (NRT) are efficacious tobacco dependence treatments, there is substantial interindividual variability in therapeutic response and most smokers relapse. Pharmacogenetics research may improve treatment outcomes by identifying genetic variants predictive of therapeutic response. We investigated the roles of two functional genetic variants in the dopamine D2...
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