Article
Genome-wide association study identifies four genetic loci associated with thyroid volume and goiter risk.
American journal of human genetics - 13 May 2011
Teumer Alexander, Rawal Rajesh, Homuth Georg, Ernst Florian, Heier Margit, Evert Matthias, Dombrowski Frank, Völker Uwe, Nauck Matthias, Radke Dörte, Ittermann Till, Biffar Reiner, Döring Angela, Gieger Christian, Klopp Norman, Wichmann H-Erich, Wallaschofski Henri, Meisinger Christa, Völzke Henry
Abstract excerpt
Thyroid disorders such as goiters represent important diseases, especially in iodine-deficient areas. Sibling studies have demonstrated that genetic factors substantially contribute to the interindividual variation of thyroid volume. We performed a genome-wide association study of this phenotype by analyzing a discovery cohort consisting of 3620 participants of the Study of Health in Pomerania (SHIP). Four...
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