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Article

Activation of the hedgehog signaling pathway in the developing lens stimulates ectopic FoxE3 expression and disruption in fiber cell differentiation.

Investigative ophthalmology & visual science - 5 Jun 2012

Kerr Christine L, Huang Jian, Williams Trevor, West-Mays Judith A

Abstract excerpt

PURPOSE: The signaling pathways and transcriptional effectors responsible for directing mammalian lens development provide key regulatory molecules that can inform our understanding of human eye defects. The hedgehog genes encode extracellular signaling proteins responsible for patterning and tissue formation during embryogenesis. Signal transduction of this pathway is mediated through activation of the...

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Share to Cell Death
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Forkhead Transcription Factors

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Share to Lens, Crystalline

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Identifiers

PMID: 22491411
DOI: 10.1167/iovs.12-9595
PMCID: PMC3385968

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Activation of the hedgehog signaling pathway in the developing lens stimulates ectopic FoxE3 expression and disruption in fiber cell differentiation.PMID 22491411Read ↗

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