Article
Bmp signaling is required for development of primary lens fiber cells.
Development (Cambridge, England) - 1 Aug 2002
Faber Sonya C, Robinson Michael L, Makarenkova Helen P, Lang Richard A
Abstract excerpt
We have investigated the role of Bmp signaling in development of the mouse lens using three experimental strategies. First, we have shown that the Bmp ligand inhibitor noggin can suppress the differentiation of primary lens fiber cells in explant culture. Second, we have expressed a dominant-negative form of the type 1 Bmp family receptor Alk6 (Bmpr1b -- Mouse Genome Informatics) in the lens in transgenic mice...
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