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Article

Prox1 function is crucial for mouse lens-fibre elongation.

Nature genetics - 1 Mar 1999

Wigle J T, Chowdhury K, Gruss P, Oliver G

Abstract excerpt

Although insights have emerged regarding genes controlling the early stages of eye formation, little is known about lens-fibre differentiation and elongation. The expression pattern of the Prox1 homeobox gene suggests it has a role in a variety of embryonic tissues, including lens. To analyse the requirement for Prox1 during mammalian development, we inactivated the locus in mice. Homozygous Prox1-null mice die...

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Identifiers

PMID: 10080188
DOI: 10.1038/6844

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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