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Article

Expression and Clinicopathological Significance of Notch Signaling and Cell-Fate Genes in Biliary Tract Cancer

20 Sept 2011

Abstract excerpt

OBJECTIVES: Biliary tract cancer (BTC) is a fatal cancer originating from epithelial cells of the intra- and extra-hepatic biliary duct system and the gallbladder. Genes and pathways regulating stem and progenitor cells as well as cell-fate decisions are increasingly recognized in tumorigenesis. We evaluated the expression of Notch1, Notch2, and HES1 (hairy and enhancer of split 1), as well as the biliary...

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Share to Cholangiocarcinoma and Gallbladder Cancer Studies
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Identifiers

PMID: 21931375
DOI: 10.1038/ajg.2011.305

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