Article
Human and experimental evidence supporting a role for osteopontin in alcoholic hepatitis.
Hepatology (Baltimore, Md.) - 1 Nov 2013
Morales-Ibanez Oriol, Domínguez Marlene, Ki Sung H, Marcos Miguel, Chaves Javier F, Nguyen-Khac Eric, Houchi Hakim, Affò Silvia, Sancho-Bru Pau, Altamirano José, Michelena Javier, García-Pagán Juan Carlos, Abraldes Juan G, Arroyo Vicente, Caballería Juan, Laso Francisco-Javier, Gao Bin, Bataller Ramón
Abstract excerpt
UNLABELLED: We identified, in the transcriptome analysis of patients with alcoholic hepatitis (AH), osteopontin (OPN) as one of the most up-regulated genes. Here, we used a translational approach to investigate its pathogenic role. OPN hepatic gene expression was quantified in patients with AH and other liver diseases. OPN protein expression and processing were assessed by immmunohistochemistry, western blotting...
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