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Article

Follistatin operates downstream of Wnt4 in mammalian ovary organogenesis.

Developmental dynamics : an official publication of the American Association of Anatomists - 1 Jun 2004

Yao Humphrey H C, Matzuk Martin M, Jorgez Carolina J, Menke Douglas B, Page David C, Swain Amanda, Capel Blanche

Abstract excerpt

Wnt4(-/-) XX gonads display features normally associated with testis differentiation, suggesting that WNT4 actively represses elements of the male pathway during ovarian development. Here, we show that follistatin (Fst), which encodes a TGFbeta superfamily binding protein, is a downstream component of Wnt4 signaling. Fst inhibits formation of the XY-specific coelomic vessel in XX gonads. In addition, germ cells...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 15162500
DOI: 10.1002/dvdy.20042
PMCID: PMC4046253

Genes

WNT4
FST

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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