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FOXL2 and BMP2 Act Cooperatively to Regulate Follistatin Gene Expression during Ovarian Development

18 Nov 2010

Abstract excerpt

Follistatin is a secreted glycoprotein required for female sex determination and early ovarian development, but the precise mechanisms regulating follistatin (Fst) gene expression are not known. Here, we investigate the roles of bone morphogenetic protein 2 (BMP2) and forkhead-domain transcription factor L2 (FOXL2) in the regulation of Fst expression in the developing mouse ovary. Bmp2 and Fst showed similar...

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PMID: 21084449
DOI: 10.1210/en.2010-0636

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