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Article

Hepatitis C genotype 1a replicon improved through introduction of fitness mutations.

BioTechniques - 1 Apr 2012

Voitenleitner Christian, Bechtel Jill, Arfsten Ann, Hamatake Robert

Abstract excerpt

The use of subgenomic replicon systems has long been a valuable screening tool for the discovery of small molecule antivirals against Hepatitis C virus. While genotype 1a replicon systems have been widely used in stable systems, use in transient assays has been hampered by low signal. Here we des...

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Identifiers

PMID: 22482443
DOI: 10.2144/000113841

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22482443-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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