Article
DGR mutagenic transposition occurs via hypermutagenic reverse transcription primed by nicked template RNA.
Proceedings of the National Academy of Sciences of the United States of America - 21 Nov 2017
Naorem Santa S, Han Jin, Wang Shufang, Lee William R, Heng Xiao, Miller Jeff F, Guo Huatao
Abstract excerpt
Diversity-generating retroelements (DGRs) are molecular evolution machines that facilitate microbial adaptation to environmental changes. Hypervariation occurs via a mutagenic retrotransposition process from a template repeat (TR) to a variable repeat (VR) that results in adenine-to-random nucleotide conversions. Here we show that reverse transcription of the Bordetella phage DGR is primed by an adenine residue...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.