Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Distinct Antiretroviral Mechanisms Elicited by a Viral Mutagen.

Journal of molecular biology - 3 Sept 2021

Roth Megan, McDaniel Yumeng Z, Daly Michele B, Talledge Nathaniel, Greggs Willie M, Patterson Steven E, Kim Baek, Mansky Louis M

Abstract excerpt

5-aza-cytidine (5-aza-C) has been shown to be a potent human immunodeficiency virus type 1 (HIV-1) mutagen that induces G-to-C hypermutagenesis by incorporation of the reduced form (i.e., 5-aza-dC, 5-aza-dCTP). Evidence to date suggests that this lethal mutagenesis is the primary antiretroviral mechanism for 5-aza-C. To investigate the breadth of application of 5-aza-C as an antiretroviral mutagen, we have...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Tumor Virus Infections
Share to Azacitidine

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Leukemia, Experimental

Share to Leukemia Virus, Murine

Share to Mutagens

Share to Retroviridae Infections

Source

Open in PubMed Open full text

Identifiers

PMID: 34153286
DOI: 10.1016/j.jmb.2021.167111
PMCID: PMC8380735

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Distinct Antiretroviral Mechanisms Elicited by a Viral Mutagen.PMID 34153286Read ↗

Combination of a mutagenic agent with a reverse transcriptase inhibitor results in systematic inhibition of HIV-1 infection.Semantic proximity Read ↗

Lethal mutagenesis of HIV with mutagenic nucleoside analogsSemantic proximity Read ↗

5-Azacytidine Can Induce Lethal Mutagenesis in Human Immunodeficiency Virus Type 1Semantic proximity Read ↗

5,6-Dihydro-5-aza-2'-deoxycytidine potentiates the anti-HIV-1 activity of ribonucleotide reductase inhibitors.Semantic proximity Read ↗

Azidothymidine and other chain terminators are mutagenic for template-switch-generated genetic mutations.Semantic proximity Read ↗

WR1065 mitigates AZT-ddI-induced mutagenesis and inhibits viral replication.Semantic proximity Read ↗

Molecular analysis of mutations at the HPRT and TK loci of human lymphoblastoid cells after combined treatments with 3'-azido-3'-deoxythymidine and 2',3'-dideoxyinosinedagger.Semantic proximity Read ↗

Perspective - Lethal Mutagenesis of HIV by Mutagenic Ribonucleoside AnalogsSemantic proximity Read ↗

Mutagen-mediated enhancement of HIV-1 replication in persistently infected cells.Semantic proximity Read ↗

Host DNA repair factors empower a mechanism of antiviral nucleoside analog resistanceSemantic proximity Read ↗

Differential Incorporation and Removal of Antiviral Deoxynucleotides by Human DNA Polymerase γSemantic proximity Read ↗

Novel inhibitors of human immunodeficiency virus type 2 infectivitySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.