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Article

DNA damage-signaling, homologous recombination and genetic mutation induced by 5-azacytidine and DNA-protein crosslinks in Escherichia coli.

Mutation research - 1 Jan 2000

Klaric Julie A, Glass David J, Perr Eli L, Reuven Arianna D, Towne Mason J, Lovett Susan T

Abstract excerpt

Covalent linkage between DNA and proteins produces highly toxic lesions and can be caused by commonly used chemotherapeutic agents, by internal and external chemicals and by radiation. In this study, using Escherichia coli, we investigate the consequences of 5-azacytidine (5-azaC), which traps covalent complexes between itself and the Dcm cytosine methyltransferase protein. DNA protein crosslink-dependent effects...

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Identifiers

PMID: 33743507
DOI: 10.1016/j.mrfmmm.2021.111742
PMCID: PMC8288033

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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