Article
NMDAR1 autoantibodies amplify behavioral phenotypes of genetic white matter inflammation: a mild encephalitis model with neuropsychiatric relevance.
Molecular psychiatry - 1 Dec 2022
Arinrad Sahab, Wilke Justus B H, Seelbach Anna, Doeren José, Hindermann Martin, Butt Umer Javed, Steixner-Kumar Agnes A, Spieth Lena, Ronnenberg Anja, Pan Hong, Berghoff Stefan A, Hollmann Michael, Lühder Fred, Nave Klaus-Armin, Bechter Karl, Ehrenreich Hannelore
Abstract excerpt
Encephalitis has an estimated prevalence of ≤0.01%. Even with extensive diagnostic work-up, an infectious etiology is identified or suspected in <50% of cases, suggesting a role for etiologically unclear, noninfectious processes. Mild encephalitis runs frequently unnoticed, despite slight neuroinflammation detectable postmortem in many neuropsychiatric illnesses. A widely unexplored field in humans, though...
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