Effect of a functional single nucleotide polymorphism in the 2',3'-cyclic nucleotide 3'-phosphodiesterase gene on the expression of oligodendrocyte-related genes in schizophrenia.

doi:10.1111/j.1440-1819.2007.01786.x

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Article

Effect of a functional single nucleotide polymorphism in the 2',3'-cyclic nucleotide 3'-phosphodiesterase gene on the expression of oligodendrocyte-related genes in schizophrenia.

Psychiatry and clinical neurosciences - 1 Feb 2008

Iwamoto Kazuya, Ueda Junko, Bundo Miki, Nakano Yoko, Kato Tadafumi

Abstract excerpt

AIMS: Although the expression of oligodendrocyte-related genes in post-mortem brains of patients with schizophrenia is consistently reported to be downregulated, the cause of the change remains unclear. The A-allele of rs2070106 within the 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNP), an oligodendrocyte-related gene, was reported to show reduced expression compared with the G-allele, and proposed to be...

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PMID: 18289148
DOI: 10.1111/j.1440-1819.2007.01786.x

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