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IL28B polymorphisms predict interferon-related hepatitis B surface antigen seroclearance in genotype D hepatitis B e antigen-negative patients with chronic hepatitis B.

Hepatology (Baltimore, Md.) - 1 Mar 2013

Lampertico Pietro, Viganò Mauro, Cheroni Cristina, Facchetti Floriana, Invernizzi Federica, Valveri Vincenza, Soffredini Roberta, Abrignani Sergio, De Francesco Raffaele, Colombo Massimo

Abstract excerpt

UNLABELLED: Interleukin (IL)28B polymorphisms have been associated with interferon (IFN)-induced viral clearance in patients with chronic hepatitis C. Whether this is also true for patients with the difficult-to-cure hepatitis B e antigen (HBeAg)-negative chronic hepatitis B (CHB) is unknown. One hundred and one HBeAg-negative patients (92% genotype D) with compensated CHB (84% males, 46 years; hepatitis B virus...

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PMID: 22473858
DOI: 10.1002/hep.25749

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