IL28B alleles associated with poor hepatitis C virus (HCV) clearance protect against inflammation and fibrosis in patients infected with non-1 HCV genotypes.

doi:10.1002/hep.24678

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

IL28B alleles associated with poor hepatitis C virus (HCV) clearance protect against inflammation and fibrosis in patients infected with non-1 HCV genotypes.

Hepatology (Baltimore, Md.) - 1 Feb 2012

Bochud Pierre-Yves, Bibert Stéphanie, Kutalik Zoltán, Patin Etienne, Guergnon Julien, Nalpas Bertrand, Goossens Nicolas, Kuske Lorenz, Müllhaupt Beat, Gerlach Tillman, Heim Markus H, Moradpour Darius, Cerny Andreas, Malinverni Raffaele, Regenass Stephan, Dollenmaier Guenter, Hirsch Hans, Martinetti Gladys, Gorgiewski Meri, Bourlière Marc, Poynard Thierry, Theodorou Ioannis, Abel Laurent, Pol Stanislas, Dufour Jean-François, Negro Francesco

Abstract excerpt

UNLABELLED: Genetic polymorphisms near IL28B are associated with spontaneous and treatment-induced clearance of hepatitis C virus (HCV), two processes that require the appropriate activation of the host immune responses. Intrahepatic inflammation is believed to mirror such activation, but its relationship with IL28B polymorphisms has yet to be fully appreciated. We analyzed the association of IL28B polymorphisms...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Disease Progression

Share to Hepacivirus

Share to Hepatitis C, Chronic

Share to Interferons

Share to Interleukins

Share to Liver Cirrhosis

Share to Young Adult

Source

Open in PubMed

Identifiers

PMID: 22180014
DOI: 10.1002/hep.24678

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

IL28B alleles associated with poor hepatitis C virus (HCV) clearance protect against inflammation and fibrosis in patients infected with non-1 HCV genotypes.PMID 22180014Read ↗

Interleukin-28B rs12979860 C allele: Protective against advanced fibrosis in chronic hepatitis C genotype 1 infection.Semantic proximity Read ↗

Association of IL28B genotype with fibrosis progression and clinical outcomes in patients with chronic hepatitis C: a longitudinal analysis.Semantic proximity Read ↗

The association of IL28B genotype with the histological features of chronic hepatitis C is HCV genotype dependent.Semantic proximity Read ↗

IL28B polymorphism and genetic biomarkers of viral clearance in hepatitis C virus infection.Semantic proximity Read ↗

Association of IL28B SNP With Progression of Egyptian HCV Genotype 4 Patients to End Stage Liver DiseaseSemantic proximity Read ↗

Interleukin-28B gene non-TT allele strongly predicts treatment failure for genotype 1 infected chronic hepatitis C patients with advanced fibrosis: a case control study.Semantic proximity Read ↗

Genetic variation in IL28B is associated with chronic hepatitis C and treatment failure: a genome-wide association study.Semantic proximity Read ↗

Interleukin-28B genetic variants in untreated Italian HCV-infected patients: a multicentre study.Semantic proximity Read ↗

Impact of immunogenetic IL28B polymorphism on natural outcome of HCV infection.Semantic proximity Read ↗

Impact of IL28B genetic variation on HCV-induced liver fibrosis, inflammation, and steatosis: a meta-analysis.Semantic proximity Read ↗

Impact of IL28B-related single nucleotide polymorphisms on liver histopathology in chronic hepatitis C genotype 2 and 3.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.